Parekh Lab for Motivational, Affective, and Cognitive Systems @ UT Dallas BBS - Department of Neuroscience

Publications

2023

A stress-sensitive frontostriatal circuit supporting effortful reward-seeking behavior
A stress-sensitive frontostriatal circuit supporting effortful reward-seeking behavior
Robert N. Fetcho, Puja K. Parekh, Jolin Chou, Margaux Kenwood, Laura Chalençon, David J. Estrin, Megan Johnson, Conor Liston
Neuron  ·  13 Nov 2023  ·  doi:10.1016/j.neuron.2023.10.020

2022

Synaptic Mechanisms Regulating Mood State Transitions in Depression
Synaptic Mechanisms Regulating Mood State Transitions in Depression
Puja K. Parekh, Shane B. Johnson, Conor Liston
Annual Review of Neuroscience  ·  04 May 2022  ·  doi:10.1146/annurev-neuro-110920-040422
Circadian transcription factor NPAS2 and the NAD<sup>+</sup>‐dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward
Circadian transcription factor NPAS2 and the NAD+‐dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward
Darius D. Becker‐Krail, Puja K. Parekh, Kyle D. Ketchesin, Shintaro Yamaguchi, Jun Yoshino, Mariah A. Hildebrand, Brandan Dunham, Madhavi K. Ganapathiraju, Ryan W. Logan, Colleen A. McClung
European Journal of Neuroscience  ·  22 Jan 2022  ·  doi:10.1111/ejn.15596

2020

Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2
Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2
Ryan W. Logan, Angela R. Ozburn, Rachel N. Arey, Kyle D. Ketchesin, Alicia Winquist, …, Lauren M. DePoy, Mariah A. Hildebrand, Evan Y. Snyder, George C. Tseng, Colleen A. McClung
Molecular Psychiatry  ·  04 Nov 2020  ·  doi:10.1038/s41380-020-00958-2

2019

Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo
Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo
Amanda Acosta-Ruiz, Vanessa A. Gutzeit, Mary Jane Skelly, Samantha Meadows, Joon Lee, …, Anna G. Orr, Conor Liston, Kristen E. Pleil, Johannes Broichhagen, Joshua Levitz
Neuron  ·  26 Nov 2019  ·  doi:10.1016/j.neuron.2019.10.036
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
R. N. Moda-Sava, M. H. Murdock, P. K. Parekh, R. N. Fetcho, B. S. Huang, …, T. A. Milner, K. Deisseroth, H. Bito, H. Kasai, C. Liston
Science  ·  12 Apr 2019  ·  doi:10.1126/science.aat8078
Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2
Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2
Puja K. Parekh, Ryan W. Logan, Kyle D. Ketchesin, Darius Becker-Krail, Micah A. Shelton, Mariah A. Hildebrand, Kelly Barko, Yanhua H. Huang, Colleen A. McClung
The Journal of Neuroscience  ·  08 Apr 2019  ·  doi:10.1523/JNEUROSCI.2233-18.2019

2018

NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward
NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward
Ryan W. Logan, Puja K. Parekh, Gabrielle N. Kaplan, Darius D. Becker-Krail, Wilbur P. Williams, …, Jeffrey Oliver-Smith, Poornima Sundarvelu, John F. Enwright, Yanhua H. Huang, Colleen A. McClung
Molecular Psychiatry  ·  04 May 2018  ·  doi:10.1038/s41380-018-0061-1
Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge‐Like Alcohol Drinking in Mice
Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge‐Like Alcohol Drinking in Mice
Kush Purohit, Puja K. Parekh, Joseph Kern, Ryan W. Logan, Zheng Liu, Yanhua Huang, Colleen A. McClung, John C. Crabbe, Angela R. Ozburn
Alcoholism: Clinical and Experimental Research  ·  18 Apr 2018  ·  doi:10.1111/acer.13626

2017

NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors
NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors
Angela R. Ozburn, Joseph Kern, Puja K. Parekh, Ryan W. Logan, Zheng Liu, …, Darius Becker-Krail, Kush Purohit, Nicole M. Edgar, Yanhua Huang, Colleen A. McClung
Frontiers in Molecular Neuroscience  ·  03 Nov 2017  ·  doi:10.3389/fnmol.2017.00360
Antimanic Efficacy of a Novel Kv3 Potassium Channel Modulator
Antimanic Efficacy of a Novel Kv3 Potassium Channel Modulator
Puja K Parekh, Michelle M Sidor, Andrea Gillman, Darius Becker-Krail, Letizia Bettelini, …, Erika Zambello, Chiara Mutinelli, Yanhua Huang, Charles H Large, Colleen A McClung
Neuropsychopharmacology  ·  31 Aug 2017  ·  doi:10.1038/npp.2017.155
Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania
Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania
Puja K. Parekh, Darius Becker-Krail, Poornima Sundaravelu, Shinsuke Ishigaki, Haruo Okado, Gen Sobue, Yanhua Huang, Colleen A. McClung
Biological Psychiatry  ·  17 Jun 2017  ·  doi:10.1016/j.biopsych.2017.06.022

2016

Functional Implications of the CLOCK 3111T/C Single-Nucleotide Polymorphism
Functional Implications of the CLOCK 3111T/C Single-Nucleotide Polymorphism
Angela R. Ozburn, Kush Purohit, Puja K. Parekh, Gabrielle N. Kaplan, Edgardo Falcon, Shibani Mukherjee, Hannah M. Cates, Colleen A. McClung
Frontiers in Psychiatry  ·  21 Apr 2016  ·  doi:10.3389/fpsyt.2016.00067
Circadian Mechanisms Underlying Reward-Related Neurophysiology and Synaptic Plasticity
Circadian Mechanisms Underlying Reward-Related Neurophysiology and Synaptic Plasticity
Puja K. Parekh, Colleen A. McClung
Frontiers in Psychiatry  ·  12 Jan 2016  ·  doi:10.3389/fpsyt.2015.00187

2015

Circadian clock genes: Effects on dopamine, reward and addiction
Circadian clock genes: Effects on dopamine, reward and addiction
Puja K. Parekh, Angela R. Ozburn, Colleen A. McClung
Alcohol  ·  08 Jan 2015  ·  doi:10.1016/j.alcohol.2014.09.034
Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice
Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice
M M Sidor, S M Spencer, K Dzirasa, P K Parekh, K M Tye, …, S Kumar, E M Remillard, M G Caron, K Deisseroth, C A McClung
Molecular Psychiatry  ·  06 Jan 2015  ·  doi:10.1038/mp.2014.167

2014

Experience-dependent regulation of presynaptic NMDARs enhances neurotransmitter release at neocortical synapses
Experience-dependent regulation of presynaptic NMDARs enhances neurotransmitter release at neocortical synapses
Joanna Urban-Ciecko, Jing A. Wen, Puja K. Parekh, Alison L. Barth
Learning & Memory  ·  15 Dec 2014  ·  doi:10.1101/lm.035741.114
TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor
TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor
Yong Chen, Patrick Kanju, Quan Fang, Suk Hee Lee, Puja K. Parekh, …, Carlene Moore, Daniel Brenner, Robert W. Gereau, Fan Wang, Wolfgang Liedtke
Pain  ·  02 Oct 2014  ·  doi:10.1016/j.pain.2014.09.033
TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour
TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour
Amanda S. Lindy, Puja K. Parekh, Richard Zhu, Patrick Kanju, Sree V. Chintapalli, Volodymyr Tsvilovskyy, Randen L. Patterson, Andriy Anishkin, Damian B. van Rossum, Wolfgang B. Liedtke
Nature Communications  ·  02 Sep 2014  ·  doi:10.1038/ncomms5734

2013

Effects of Perinatal Lipopolysaccharide (LPS) Exposure on the Developing Rat Brain; Modeling the Effect of Maternal Infection on the Developing Human CNS
Effects of Perinatal Lipopolysaccharide (LPS) Exposure on the Developing Rat Brain; Modeling the Effect of Maternal Infection on the Developing Human CNS
M. Xu, Z. L. Sulkowski, P. Parekh, A. Khan, T Chen, …, T. Iwasaki, N. Shimokawa, N. Koibuchi, A. M. Zavacki, E. M. Sajdel-Sulkowska
The Cerebellum  ·  12 Aug 2013  ·  doi:10.1007/s12311-013-0465-z
Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion
Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion
Yong Chen, Susan H. Williams, Amy L. McNulty, Ji Hee Hong, Suk Hee Lee, …, Robert W. Gereau, Andrea B. Taylor, Fan Wang, Farshid Guilak, Wolfgang Liedtke
Pain  ·  06 Apr 2013  ·  doi:10.1016/j.pain.2013.04.004